For Type 2 Diabetes

• Starting Dose: 0.25 mg once weekly for 4 weeks; this dose is intended for treatment initiation and is not effective for glycemic control.
• Maintenance Dose: After the initial 4 weeks, increase to 0.5 mg once weekly. If additional glycemic control is needed, the dose may be increased after at least 4 weeks to 1.0 mg once weekly, and potentially further to 2.0 mg once weekly based on efficacy and tolerability.

For Weight Loss

• Starting Dose: 0.25 mg once weekly for 4 weeks.
• Incremental Increases: The dose is then increased every 4 weeks through a step-wise approach:
  • Increase to 0.5 mg once weekly for 4 weeks.
  • Then to 1.0 mg once weekly for 4 weeks.
  • Followed by 1.7 mg once weekly for 4 weeks.
  • And finally, to 2.4 mg once weekly.

The gradual increase in dosing for both uses is designed to improve gastrointestinal tolerability, as semaglutide can cause side effects such as nausea and diarrhea, particularly when treatment is initiated or doses are increased.

It is essential that semaglutide be administered on the same day each week, and it can be taken at any time of day, with or without meals. If a dose is missed, it should be taken as soon as possible within 5 days after the missed day. If more than 5 days have passed, the missed dose should be skipped, and the next dose should be taken on the regularly scheduled day.

Always follow the specific dosing instructions provided by a healthcare provider, who will tailor the regimen based on individual health needs and treatment responses.