Tirzepatide, sold under the brand name Mounjaro, is used primarily for the treatment of type 2 diabetes and weight loss. Its dosing schedule involves a gradual increase to help manage potential side effects and optimize its effectiveness. Here’s a breakdown of the common dosing regimen for tirzepatide when used for weight loss

Initial Dosing and Titration

• Starting Dose: 2.5 mg injected subcutaneously (under the skin) once a week.
• First Increase: After 4 weeks, increase to 5 mg once weekly.
• Subsequent Increases: Depending on the individual’s response and tolerability, the dose can be increased every 4 weeks:
  • From 5 mg to 7.5 mg once weekly.
  • Then from 7.5 mg to 10 mg once weekly.
  • And potentially to 15 mg once weekly as the maximum dose.

Considerations

• The titration schedule is designed to minimize gastrointestinal side effects, which are common with GLP-1 receptor agonists like tirzepatide. These side effects typically include nausea, diarrhea, and vomiting.
• The dose may be adjusted based on the patient's glycemic response and is not necessarily increased to the maximum unless needed for better blood sugar control.
• It's important to administer tirzepatide on the same day each week to maintain consistent blood levels of the medication.

Monitoring and Adjustments

Patients using tirzepatide should have regular follow-up appointments to monitor their response to the medication, side effects, and any potential adjustments to the dose. Blood glucose levels, weight, and other health markers are typically monitored to assess effectiveness and safety.

If you are considering tirzepatide for weight loss, it is crucial to consult with a healthcare provider to ensure it is appropriate for your specific health needs and to discuss any potential interactions with other medications you may be taking.