Semaglutide is primarily available as an injectable medication under the brand names Ozempic, Rybelsus, and Wegovy, used for the treatment of type 2 diabetes and weight loss. However, for those seeking non-injectable options, semaglutide is also available in an oral form:

Rybelsus is the oral form of semaglutide. It was the first oral glucagon-like peptide-1 (GLP-1) receptor agonist approved for use. Rybelsus is taken as a daily tablet and is used for the treatment of type 2 diabetes. It offers an alternative for patients who are not comfortable with injections or who prefer a pill-based treatment. While the oral form is effective for managing blood sugar levels in type 2 diabetes, its use for weight loss is not as well-established as the injectable forms, which have been more prominently studied and utilized in weight management.

Compounded semaglutide is also available in an oral form for those who prefer the convenience of a daily medication vs a weekly injection. The oral for has the added benefit of being shelf stable at room temperature where the injectable needs to be refrigerated.

Patients considering switching from injectable to oral forms, or starting on semaglutide, should discuss with their healthcare provider to determine the most appropriate form and treatment regimen based on their health needs and personal preferences.